WebMay 18, 2024 · In PNAS, He et al. describe a mechanism for macrophage cholesterol efflux, which involves the transfer of surplus cholesterol from the macrophage plasma … WebABCA1 is necessary for the transport of cholesterol and phospholipids to apolipoprotein -I and the biosynthesis of HDL; while ABCG1 mainly promotes the efflux of cholesterol to HDL (Wang and Westerterp, 2024). When ABCA1 expression is increased in macrophages, cholesterol efflux is increased, and foam cell formation is reduced (Price et al., 2024).
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WebNov 1, 2012 · Because activation of cholesterol efflux pathways can inhibit stem cell proliferation, mobilization, and monocyte production, this may provide a rationale for … WebMar 16, 2016 · Cholesterol is a key component of membrane lipids, and has been shown to be required for T-cell receptor (TCR) clustering and the formation of the T-cell immunological synapse 13, 14, 15.... davy annual report
Cholesterol Efflux Pathways Suppress Inflammasome Activation, …
WebDec 7, 2024 · Defective efflux of cholesterol in T cells promotes clustering of TCR and cytokine components in lipid rafts, leading to augmented T cell signaling, activation, and effector Th cell differentiation. Enhanced … WebDec 2, 2024 · Upon T-cell activation, genes involved in cholesterol biosynthesis are upregulated while genes that promote cholesterol efflux are repressed. HDAC3-deficient CD4 + T cells had reduced levels of cellular cholesterol both before and after activation. HDAC3-deficient cells upregulate cholesterol synthesis appropriately after activation, … WebCholesterol is an essential component of all cell membranes and particularly enriched in myelin membranes. Myelin membranes are a major target of immune attacks in the chronic neurological disorder multiple sclerosis (MS). During demyelinating insults, cholesterol is released from damaged myelin, increasing local levels of this unique lipid and impeding … davy beauce bridgepoint