Cryptophycin-52
WebJul 1, 2000 · Cryptophycin 52 (0.3 mg/kg IV given on days 7, 9, and 11) is also efficacious in rats bearing the 13762 mammary carcinoma (104). Additive and supra-additive effects are noted in human tumor... Members of the cryptophycin family have been studied as anti-tumor agents. Cryptophycin-52, a synthetic analog of natural product cryptophycins also known as LY355703, reached phase II clinical trials but was withdrawn due to side effects.
Cryptophycin-52
Did you know?
WebNov 15, 2024 · Consequently, Cryptophycin 52, a synthetic analogue, was developed and used for clinical trials. It was chosen because no large-scale biotechnological production method existed for the cryptophycins. However, the high-production costs and toxic side effects of cryptophycin 52 stopped its development. WebMar 1, 2003 · Cryptophycin 52 is a novel antitubulin drug with in vitro and in vivo activity in non-small cell lung cancer. Based upon promising Phase 1 data, a multicenter trial was performed to evaluate the...
WebCryptophycin 52 C36H45ClN2O8 CID 9939639 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... WebFeb 3, 2024 · A synthetic analog, cryptophycin-52 (Figure 1) that contains a geminal dimethyl functionality in unit C entered clinical trials for both the treatment of platinum resistant ovarian cancer and non-small cell lung cancer. 10–12 Despite showing significant disease stabilization and an overall positive result, the trials were discontinued due to ...
WebDec 1, 2002 · A new addition to the family of microtubule targeting agents is cryptophycin 52 (LY355703), a macrocyclic depsipeptide ().It is a synthetic analogue of naturally occurring cryptophycins isolated from the blue-green algae species Nostoc .Cryptophycin 52 binds to the Vinca domain of microtubules, inhibits microtubule polymerization, and is the … Web用于防止癌细胞转移的化合物、组合物和方法专利检索,用于防止癌细胞转移的化合物、组合物和方法属于肝细胞生物学专利检索,找专利汇即可免费查询专利,肝细胞生物学专利汇是一家知识产权数据服务商,提供专利分析,专利查询,专利检索等数据服务功能。
WebOct 20, 2009 · Cryptophycins are a family of highly cytotoxic, cyclic depsipeptides. They display antitumour activity that is largely maintained for multi-drug-resistant tumour cells. …
WebCryptophycin 1 is one of the most potent tubulin-destabilizing agents ever discovered, resulting in cellular arrest at the G2/M phase via hyperphosphorylation of Bcl-2, thereby … bishop drumm iowaWebFor instance, the synthetic analog cryptophycin 52 (1), which progressed to Phase II clinical trials for the treatment of patients with platinum-resistant ovarian cancer, is based on the cryptophycin 1 (2) which was isolated from terrestrial cyanobacteria [7,8]. … bishop drumm des moines iaWebConformational changes in tubulin upon binding Cryptophycin-52 reveal its mechanism of action Conformational changes in tubulin upon binding Cryptophycin-52 reveal its mechanism of action J Biol Chem. 2024 Aug 27;101138. doi: 10.1016/j.jbc.2024.101138. Online ahead of print. Authors dark heart 1986WebJan 1, 2024 · Cryptophycin 1 and 52 is another such compound with a similar effect. Cryptophycins, also known for microtubule targeting, activates cysteine proteases CPP32, that is, caspase-3, YAMA, apopain (an ICE/CED-3-like a protease member of apoptosis effector family) and causes irregular mitotic spindles formation culminated in the … bishop drive frederictonWebJul 1, 2000 · Cryptophycin 52 (0.3 mg/kg IV given on days 7, 9, and 11) is also efficacious in rats bearing the 13762 mammary carcinoma (104). Additive and supra-additive effects … dark healing star warsWebAug 1, 2024 · Cryptophycin-52 (CR52), a tubulin inhibitor, exhibits promising antitumor activity in vitro (picomolar level) and in mouse xenograft models. However, the narrow therapeutic window in clinical trials limits its further development. Antibody-drug conjugate (ADC), formed by coupling cytotoxic compound (payload) to an antibody via a linker, can ... dark heart 2006WebThis invention concerns methods of treating a patient diagnosed with glioblastoma comprising administering to said patient a therapy comprising an effective amount of an anti-VEGF antibody and a chemotherapeutic. dark heart care bears wiki