Web16 aug. 2004 · MEGF10 and DMD double knockout animals have pronounced fiber size variability and intracellular inclusions in the quadriceps femoris with extensive endomysial connective tissue infiltration. Mice develop muscle weakness, kyphosis and a waddling gait. At 2 months of age, they have reduced contractile force compared to wild-type mice. WebBexarotene enhances astrocyte phagocytosis via ABCA1-mediated pathways in a mouse model of subarachnoid hemorrhage. Bex enhanced astrocyte phagocytosis through the …
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Web13 apr. 2024 · Chung WS, Clarke LE, Wang GX, Stafford BK, Sher A, Chakraborty C, et al. Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways. Nature. 2013; ... The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain - Science Advances - June 25th, 2024 [June 25th, 2024] Web20 mei 2014 · Astrocytes are known to serve various important roles within neural circuits, but the possibility that they may also contribute to, or perhaps even drive disease mechanisms, remains incompletely explored. bangi daerah apa
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Web11 mei 2016 · Abstract. Multiple EGF-like domains 10 (Megf10) is a class F scavenger receptor (SR-F3) expressed on astrocytes and myosatellite cells, and recessive … Web28 dec. 2024 · Finally, Megf10-knockout mice show defective long-term synaptic plasticity and impaired formation of hippocampal memories. Together, our data provide strong evidence that astrocytes eliminate unnecessary excitatory synaptic connections in the adult hippocampus through MEGF10, and that this astrocytic function is crucial for maintaining … Web7 jan. 2024 · In 2013, Chung et al., demonstrated that astrocytes and microglia participate in synapse elimination via two activity-dependent phagocytic receptors, MEGF10 and MERTK, which trigger engulfment of excitatory and inhibitory synapses in the developing mouse visual system (Fig. 2 c). arwana nuansa keramik tbk