WebRecombinant Human Siglec-9 Fc Chimera Protein, CF Cat # 1139-SL Citations (10) Recombinant Mouse Siglec-E Fc Chimera Protein, CF Cat # 5806-SL Citations (3) Recombinant Human Siglec-14 Fc Chimera Protein, CF Cat # 4905-SL Human PD-1 Alexa Fluor® 405-conjugated Antibody Cat # FAB10863V Recombinant Human Siglec-11 Fc … WebIn peripheral blood leukocytes, Siglec-9 is expressed on neutrophils, monocytes, a fraction of NK cells, B cells, and a minor subset of CD8+ T cells (5). It binds equally well to both 2,3- and 2,6-linked sialic acid (5, 6). …
Siglec9, Fc Fusion, Avi-tag, 100558-2 AMSBIO
Websecreting Siglec-Fc proteins were prepared following standard methods (15). Generation of Monoclonal Antibodies to Siglec-9—Balb/c mice were immunized three times with 10 mg … drive 3 roma
A versatile soluble siglec scaffold for sensitive and
WebLigands for Siglec-9 are up-regulated in human carcinomas. (A) LS180 (colorectal cancer, CRC) and A549 (NSCLC) cell lines were probed for Siglec-9 ligands using hSiglec-9–Fc chimera (red line) against control (R120K, blue line) or second reagent alone (solid gray). Histograms are shown. WebNov 29, 2024 · Siglec-9 is an immune checkpoint target and an immunoinhibitory receptor that can engage either sialic acid ligands or agonistic antibodies. Through Siglec-9 sialic acid interactions, activated immunoreceptor tyrosine-based inhibitory signaling of the immune cells can lead to unfavorable immunosuppression. WebIt is highly expressed on neutrophils and monocytes, and at lower levels on the subpopulations of T and B lymphocytes and NK cells. Siglec-9 plays a role in negative … drive 4bit