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Trimethyltin and cancer

WebInstitute of Cancer Research (ICR) mice were fed a control or a methoxsalen-supplemented diet for 4 weeks, and then learning and memory enhancing effects with respect to trimethyltin (TMT)-induced neurotoxicity were evaluated. The brain tissues of ICR mice were dissected after completion of the behavioral tests for biochemical analysis. WebTrimethyltin-induced hippocampal neurodegeneration: A mechanism-based review 2016 Jul;125:187-99. doi: 10.1016/j.brainresbull.2016.07.010. Epub 2016 Jul 20. Authors Sueun Lee 1 , Miyoung Yang 2 , Jinwook Kim 1 , Sohi Kang 1 , Juhwan Kim 1 , Jong-Choon Kim 1 , Chaeyong Jung 3 , Taekyun Shin 4 , Sung-Ho Kim 1 , Changjong Moon 5 Affiliations

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WebTrimethyltin produces a frequency-specific and dose-dependent auditory impairment. It preferentially affects the outer hair cells of the basal cochlea. Trimethyltin will produce morphologic changes in as little as 12 hours, with vacuolation of the outer hair cells visible by transmission electron microscopy. WebOct 7, 2011 · TRIM24 is a potent liver-specific tumour suppressor in mice and attenuates RARα-mediated transcription. TRIM28 (also known as TIF1β and KAP1) is highly … qnap home directory https://itsbobago.com

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WebTrimethyltin produces a frequency-specific and dose-dependent auditory impairment. It preferentially affects the outer hair cells of the basal cochlea. Trimethyltin will produce morphologic changes in as little as 12 hours, with vacuolation of the outer hair cells visible by transmission electron microscopy. WebFeb 22, 2024 · Trimethyltin (TMT) is a potent neurotoxicant that affects various regions within the central nervous system, including the neocortex, cerebellum, and hippocampus. In the present study, ginsenoside Rd was investigated as a candidate neuroprotective agent in a primary hippocampal neuron culture and mouse models. TMT induced neurotoxicity in a … WebList of clinical and research, molecular, cytogenetic, biochemical and serology tests for human health and Mendelian disorders, pharmacogenetic drug responses, somatic phenotypes, complex conditions and infectious diseases. qnap history

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Trimethyltin and cancer

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WebThus, agents that are able to interfere with their function increase the risk of cancer and/or infection. A series of triorganotins, (trimethyltin (TMT), dimethylphenyltin (DMPT), methyldiphenyltin (MDPT), and triphenyltin (TPT)) have been shown to decrease the lytic function of human NK cells. WebMar 1, 2024 · Trimethyltin induces apoptosis and necroptosis of mouse liver by oxidative stress through YAP phosphorylation. Yuqi Wang, Xiaojing Liu, Hongyuan Jing, ... PGRMC1 Promotes Progestin-Dependent Proliferation of Breast Cancer Cells by Binding Prohibitins Resulting in Activation of ERα Signaling. Ying Bai, M. Ludescher, +13 authors H. Neubauer ...

Trimethyltin and cancer

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WebTrimethyltin chloride is an organotin reagent widely used in transferring trimethylstannyl groups onto the substrates to synthesize various organostannanes. Trimethylstannyl … Web17.2.4 Betaine. Betaine (trimethyl glycine) ( Figure 17.1) is a metabolite formed in the body from choline. It is a natural constituent of beets, broccoli, grains, shellfish, spinach, and …

WebApr 6, 2024 · NiCl 2, a compound containing nickel, is extremely toxic to both humans and laboratory animals ( 1 ). Studies have shown that exposure to NiCl 2 is carcinogenic. NiCl 2 have the potential to cause cancer through various mechanisms, including oxidative stress, genomic DNA damage, epigenetic changes, and activation of transcription factors ( 2 ). WebApr 11, 2024 · Ginsenoside compound K has been proven to have a range of anti-cancer activities against lung cancer, leukemia, breast cancer, and colon cancer [8,9,10,11]. Ginsenoside Rh2 shows anti-cancer activity against lung cancer and liver cancer by mediating the apoptosis of cancer cells and suppressing cell proliferation and migration [ …

WebMay 22, 2024 · Trimethyltin was first described as a potent nephrotoxicant in two studies where this compound was orally administered in rats (28, 41). TMT induced rats to a renal … WebTrimethyltin produces a frequency-specific and dose-dependent auditory impairment. Like many other ototoxicants, it preferentially affects the outer hair cells of the basal (high-frequency) areas of the cochlea. Electrophysiological changes in the compound action potential can be detected within minutes.

WebTrimethyltin is an intermediate by-product in the production of other more commonly used tin products. 3 It, ... Case Study 39: Residential Radon Exposure and Lung Cancer in Sweden 695–700; Case Study 40: Community Oubreaks of Asthma Associated with Inhalation of Soybean Dust 701–706;

WebJoel G. Pounds, Lee Ann McCue, Bobbie-Jo M. Webb-Robertson, 2010, Journal of proteome research. qnap google photo syncWebA series of triorganotins, (trimethyltin (TMT), dimethylphenyltin (DMPT), methyldiphenyltin (MDPT), and triphenyltin (TPT)) have been shown to decrease the lytic function of human NK cells. TPT and MDPT were much more effective than DMPT or TMT at reducing lytic … qnap hypervisorWebTrimethyltin (TMT) is an environmental neurotoxin that mediates dopaminergic neuronal injury in the brain. In this study, we characterized the toxic mechanism and possible protective compounds against TMT-induced neurotoxicity in human dopaminergic neuroblastoma SH-SY5Y cells. Antioxidants such as melatonin, N-acetylcysteine (NAC), α … qnap ironwolf health management